Research Project Portfolio
Comprehensive visual documentation of breakthrough research in pharmaceutical sciences
Integrated Drug Discovery & Development
This comprehensive framework demonstrates our end-to-end approach to drug discovery, beginning with natural product screening from medicinal plants (Tecomella, Grewia) and marine phytoconstituents.
The integrates bioassay-guided isolation using HPLC and GC/MS, computational design through molecular docking and ADME-Tox prediction, and pharmaceutical development including API production and quality control.
Pathological Targets & Therapeutics
This research framework connects pathological targets with natural therapeutic solutions. Left panel: HCV, cancer cell lines (Huh-H7, HCT-116), and gut microbiome targets.
Right panel: medicinal plants (Tecomella undulata, Grewia asiatica, Solanum species), API production via fermentation, probiotic therapies, and bioactive nanoparticles for drug delivery.
HCV Lifecycle & Medicinal Compounds
This molecular diagram illustrates the complete hepatitis C virus replication cycle and identifies specific inhibition sites targeted by medicinal plant compounds.
Dual inhibition mechanisms: NS3/4A protease blocking prevents viral protein maturation. The workflow traces HCV from cell receptor binding through translation, RNA replication by NS5B polymerase, virion assembly, to viral egress. Natural antivirals from Solanum nigrum, Acacia nilotica, and Silymarin published in Virology Journal (IF: 6.7).
Microbial Production of Active Pharmaceutical Ingredients
A comprehensive 5-step bioprocess workflow: 1) Microbial Strain Selection - High-yield strains genetically engineered for optimal production. 2) Fermentation - Large-scale controlled growth with nutrients. 3) Harvesting & Extraction - Cell separation and lysis to release API. 4) Purification - Chromatography techniques for pharmaceutical-grade quality. 5) Purified API - Final powder for drug formulation.